2-(2-Thienyl)-5-phenylthiazolo[2,3-b]-1,3,4-thiadiazole was synthesized and evaluated for its diuretic action. The effect of 2-substitution on the ease of cyclization to a bicyclic system was studied. The carboxylic acid hydrazides were converted to dithio-carbazates which, on cyclization, gave 2-substituted 5-thio-1,3,4-thiadiazoles. Thiothiadiazoles were converted to the bicyclic system by the action of phenacyl bromide.

This bicyclic thiadiazole shows diuretic action and can be synthesized by combining 2-thienyl-5-phenylthiazolo(2,3-b)-1,3,4-thiadiazole with 2-thio-1,3,4-thiadiazole.

Paper

Bicyclic thiadiazoles. I. 2-(2-thienyl)-5-phenylthiazolo(2,3-b)-1,3,4-thiadiazole.

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