Paper
Biosynthesis of sulphated hydroxypentylmercapturic acids and the metabolism of 1-bromopentane in the rat.
Published Mar 1, 1972 · F. Grasse, S. James
Xenobiotica; the fate of foreign compounds in biological systems
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Abstract
1. Rats dosed with 1-bromopentane excrete in addition to pentylmercapturic acid, 2- and 3-hydroxypentylmercapturic acids, largely in the form of their sulphate esters; traces of 4-hydroxypentylmercapturic acid are also excreted.2. 4-Carboxybutylmercapturic acid is a metabolite of 1-bromopentane in the rat.3. The amounts of metabolites excreted by rats dosed with 1-bromopentane have been determined and confirmed by the administration of [1-14C]-1-bromopentane.
Non-RCT
Animal StudyRats dosed with 1-bromopentane excrete 2- and 3-hydroxypentylmercapturic acids, 4-carboxybutylmercapturic acid, and 4-hydroxypentylmercapturic acid as metabolites.
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