Biotransformation of 1-(4-chlorophenyl)-3,3-dimethyltriazene into 3-chloro-4-hydroxyaniline: intramolecular hydroxylation-induced chlorine migration during a catabolic degradation of a chemical carcinogen.

doi:10.1016/S0304-3835(75)95027-2

Paper

DOI: 10.1016/S0304-3835(75)95027-2

Biotransformation of 1-(4-chlorophenyl)-3,3-dimethyltriazene into 3-chloro-4-hydroxyaniline: intramolecular hydroxylation-induced chlorine migration during a catabolic degradation of a chemical carcinogen.

Published 1975 · G. Kolar, J. Schlesiger

Cancer letters

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Abstract

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Animal Study

Study Snapshot

Carcinogenic 1-(4-chlorophenyl)-3,3-dimethyltriazene is converted into 3-chloro-4-hydroxyaniline in rats, with the most abundant metabolites derived from a common 3,4-epoxy intermediate.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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