Bis(2-methoxyethyl) ether: metabolism and embryonic disposition of a developmental toxicant in the pregnant CD-1 mouse.

doi:10.1016/0272-0590(91)90096-M

Paper

DOI: 10.1016/0272-0590(91)90096-M

Bis(2-methoxyethyl) ether: metabolism and embryonic disposition of a developmental toxicant in the pregnant CD-1 mouse.

Published Apr 1, 1991 · F. Daniel, K. Cheever, Begley Kb

Fundamental and applied toxicology : official journal of the Society of Toxicology

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

The teratogenic effects of bis(2-methoxyethyl) ether in pregnant mice are due to methoxyacetic acid, which is formed either in the fetus or by hepatic metabolism in the dam and distributed to embryonic tissue.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

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Disposition of three glycol ethers administered in drinking water to male F344/N rats.

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Comparative testicular toxicity of bis(2-methoxyethyl) ether and 2-methoxyethanol in rats.

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The Role of Enzyme Induction on Metabolite Formation of Bis(2-Methoxyethyl) Ether in the Rat

Enzyme induction significantly increases the formation of methoxyacetic acid, a reproductive toxicant, in rats when given either diglyme or phenobarbital.

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Teratologic potential of 2-methoxyethanol and transplacental distribution of its metabolite, 2-methoxyacetic acid, in non-human primates.

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Metabolism of bis(2-methoxyethyl) ether in the adult male rat: evaluation of the principal metabolite as a testicular toxicant.

The testicular toxicity reported for bis(2-methoxyethyl) ether may be explained by the presence of a minor metabolite, methoxyacetic acid, in the rat's metabolism study.

1988·35citations·K. Cheever et al.·Toxicology and applied pharmacology

Toxicology and applied pharmacology

Citations

DOI: 10.1016/j.yrtph.2021.105113

Ethylene oxide derived glycol ethers: A review of the alkyl glycol ethers potential to cause endocrine disruption.

There is no significant evidence to show that ethylene glycol ethers target endocrine organs or perturb endocrine pathways, and any toxicity seen occurs through non-endocrine modes of action.

2021·6citations·J. Kelsey·Regulatory toxicology and pharmacology : RTP

Regulatory toxicology and pharmacology : RTP

DOI: 10.1016/j.yrtph.2019.104512

The urinary metabolic profile of diethylene glycol methyl ether and triethylene glycol methyl ether in Sprague-Dawley rats and the role of the metabolite methoxyacetic acid in their toxicity.

Diethylene glycol methyl ether and triethylene glycol methyl ether produce small amounts of methoxyacetic acid, which may explain their reproductive toxicity at high doses.

2019·5citations·J. Kelsey et al.·Regulatory toxicology and pharmacology : RTP

Regulatory toxicology and pharmacology : RTP

DOI: 10.1080/15287394.2012.688483

Evaluation and Comparison of Urinary Metabolic Biomarkers of Exposure for the Jet Fuel JP-8

MEAA is the most accurate biomarker for jet fuel JP-8 exposure, with BMA and PMA levels not significantly differentiating between workgroup categories after adjusting for creatinine.

2012·6citations·C. B’hymer et al.·Journal of Toxicology and Environmental Health, Part A

Journal of Toxicology and Environmental Health, Part A

DOI: 10.1007/s00420-011-0687-7

(2-Methoxyethoxy)acetic acid: a urinary biomarker of exposure for jet fuel JP-8

Urinary MEAA is an accurate biomarker of exposure for jet fuel JP-8 workers, distinguishing exposure differences by workgroup category.

2012·11citations·C. B’hymer et al.·International Archives of Occupational and Environmental Health

International Archives of Occupational and Environmental Health

DOI: 10.1016/J.TOX.2005.06.024

Short-term oral toxicity of butyl ether, ethyl hexyl ether, methyl heptyl ether and 1,6-dimethoxyhexane in male rats and the role of 2-methoxyacetic acid.

Short-term oral exposure to 1,6-dimethoxyhexane (DMH) in male rats leads to testicular damage and increased 2-methoxyacetic acid levels, indicating potential health risks for high-cetane diesel additives.

2005·9citations·R. Poon et al.·Toxicology

Toxicology