The reaction of bis-sulfone conjugation reagents with disulfide bonds allows the site-specific modification of various peptides and proteins. Herein, we present the intracellular disintegration of bis-sulfide containing somatostatin bioconjugates under controlled, tumor-relevant glutathione levels. GSH responsive release is demonstrated, which offers high potential for designing tumor responsive therapeutics.

Bis-sulfide bioconjugates with somatostatin show potential for designing tumor responsive therapeutics by triggering drug release under controlled tumor-relevant glutathione levels.

Paper

Bis-sulfide bioconjugates for glutathione triggered tumor responsive drug release.

References

Citations