Bromination Synthesis of 6-Amino-5-bromoquinoxaline

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Bromination Synthesis of 6-Amino-5-bromoquinoxaline

Published 2009 · Ha Cheng-yong

Fine chemicals

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Abstract

An efficient method using 1,3-dibromo-5,5-dimethylhydantoin as brominating agent for 6-Amino-5-bromoquinoxaline was provided.The optimum conditions were investigated when 1,3-dibromo-5,5-dimethylhydantoin,N-Bromosuccinimide and bromine were used as brominating agents.Under the optimum conditions,n(1,3-dibromo-5,5-dimethylhydantoin)∶n(6-Aminoquinoxaline)=1.0∶2.0,reaction temperature 20 ℃,CH2Cl2 as solvent and reaction time 2 h,the bromination yield can reach 97.6%.This method has many advantages,such as mild conditions,concise route and high yield without impurity.The experiment of 10 kilogram-scale has also tested performed.

Study Snapshot

This efficient method using 1,3-dibromo-5,5-dimethylhydantoin as brominating agent for 6-Amino-5-bromoquinoxaline provides mild conditions, a concise route, and high yield without impurities at 97.6%.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Bromination Synthesis of 6-Amino-5-bromoquinoxaline

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