Carbamate derivatives of 2-arylimidazo[1,2-a]pyridinium salts as acetylcholinesterase inhibitors and protective agents against organophosphorus compounds.

doi:10.1021/TX00034A018

Paper

Carbamate derivatives of 2-arylimidazo[1,2-a]pyridinium salts as acetylcholinesterase inhibitors and protective agents against organophosphorus compounds.

Published Jul 1, 1993 · R. Sundberg, D. Dalvie, J. Cordero

Chemical research in toxicology

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Abstract

A series of 2-arylimidazo[1,2-a]pyridinium salts with (N,N-dimethylcarbamoyl)oxy or (N-methylcarbamoyl)oxy groups at the 3'- or 4'-position on the phenyl substituent and various substituents on the imidazo[1,2-a]pyridine ring have been synthesized. The compounds show in vitro inhibitory activity against electric eel acetylcholinesterase (AChE), type III, and several of the compounds show protective effects toward the organophosphorus AChE inhibitor soman in mice. The possible structural relationship of these compounds to physostigmine and pyridostigmine is considered.

In Vitro Study

Study Snapshot

Carbamate derivatives of 2-arylimidazo[1,2-a]pyridinium salts show inhibitory activity against electric eel acetylcholinesterase and protective effects against organophosphorus AChE inhibitors like soman in mice.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Carbamate derivatives of 2-arylimidazo[1,2-a]pyridinium salts as acetylcholinesterase inhibitors and protective agents against organophosphorus compounds.

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References

Citations

N-Cyclohexylimidazo[1,2-a]pyridine derivatives as multi-target-directed ligands for treatment of Alzheimer's disease.

N-cyclohexylimidazo[1,2-a]pyridine derivatives show potential as multifunctional anti-Alzheimer agents due to their moderate to potent BACE1 and BuChE inhibitory and antioxidant activities.

Crystal Correlation Of Heterocyclic Imidazo[1,2-a]pyridine Analogues and Their Anticholinesterase Potential Evaluation

Imidazo[1,2-a]pyridine-based compounds with biphenyl side chain show potential as AChE inhibitors, while those with phenyl side chain exhibit better BChE inhibition effects.

Prediction of acetylcholinesterase inhibitors and characterization of correlative molecular descriptors by machine learning methods.

Machine learning methods like SVM can accurately predict acetylcholinesterase inhibitors and identify molecular descriptors associated with them, aiding in Alzheimer's disease drug discovery.