Carbamazepine and oxcarbazepine, but not eslicarbazepine, enhance excitatory synaptic transmission onto hippocampal CA1 pyramidal cells through an antagonist action at adenosine A1 receptors

doi:10.1016/j.neuropharm.2015.01.019

Paper

Carbamazepine and oxcarbazepine, but not eslicarbazepine, enhance excitatory synaptic transmission onto hippocampal CA1 pyramidal cells through an antagonist action at adenosine A1 receptors

Published Jun 1, 2015 · Sam A. Booker, Nuno Pires, S. Cobb

Neuropharmacology

Q1 SJR score

20

Citations

2

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Abstract

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Non-RCT

Animal Study

Study Snapshot

Carbamazepine and oxcarbazepine possess pro-epileptic actions at clinically-relevant concentrations by enhancing excitatory synaptic transmission, while eslicarbazepine has no such effect, explaining its lack of seizure exacerbation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Carbamazepine and oxcarbazepine, but not eslicarbazepine, enhance excitatory synaptic transmission onto hippocampal CA1 pyramidal cells through an antagonist action at adenosine A1 receptors

References

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