Carboxyethylester-polyrotaxanes as a new calcium chelating polymer: synthesis, calcium binding and mechanism of trypsin inhibition.

doi:10.1016/S0378-5173(02)00139-4

Paper

DOI: 10.1016/S0378-5173(02)00139-4

Carboxyethylester-polyrotaxanes as a new calcium chelating polymer: synthesis, calcium binding and mechanism of trypsin inhibition.

Published Aug 21, 2002 · T. Ooya, M. Eguchi, A. Ozaki

International journal of pharmaceutics

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Carboxyethylester-polyrotaxane is a novel calcium chelating polymer with a unique inhibitory effect on trypsin due to calcium chelation without non-specific interaction.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

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Multivalent interactions between biotin-polyrotaxane conjugates and streptavidin as a model of new targeting for transporters.

Biotin-polyrotaxane conjugates significantly switch from monovalent to multivalent binding to streptavidin, offering new targeting possibilities for transporters.

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Polyrotaxane-biotin conjugates effectively bind to streptavidin, suggesting their potential use as polymeric ligands in biomedical applications.

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Enhanced accessibility of peptide substrate toward membrane-bound metalloexopeptidase by supramolecular structure of polyrotaxane.

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Controllable erosion time and profile in poly(ethylene glycol) hydrogels by supramolecular structure of hydrolyzable polyrotaxane.

Cross-linked polyrotaxane-based PEG hydrogels show potential as long-term stable, hydrolyzable scaffolds for tissue engineering.

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Citations

DOI: 10.1016/j.carbpol.2024.122143

Synthesis of cyclodextrin-based polyrotaxanes and polycatenanes for supramolecular pharmaceutical sciences.

Cyclodextrin-based polyrotaxanes and polycatenanes show potential for applications in the pharmaceutical industry, with potential for future research and applications.

2024·5citations·T. Higashi et al.·Carbohydrate polymers

Carbohydrate polymers

DOI: 10.1080/14686996.2021.1935315

Weakly acidic carboxy group-grafted β-cyclodextrin-threaded acid-degradable polyrotaxanes for modulating protein interaction and cellular internalization

Carboxylation of -CD PRXs improves their intracellular uptake and potential therapeutic applications in cholesterol-related metabolic disorders without causing toxicity.

2021·10citations·Shunyao Zhang et al.·Science and Technology of Advanced Materials

Science and Technology of Advanced Materials

DOI: 10.1039/D0SM02088E

Applications of liquid crystals in biosensing.

Liquid crystals show potential in biosensing due to their high sensitivity, self-assembly potential, and chemical diversity, offering bright perspectives and advantages in biological applications.

2021·68citations·Ziyihui Wang et al.·Soft matter

Soft matter

DOI: 10.1039/d0sm02260h

Post-synthesis modification of slide-ring gels for thermal and mechanical reconfiguration.

Post-synthetic modifications of slide-ring gels enable control of thermo-responsive behavior and chemical bonding, enabling reconfiguration of properties and shapes in polyrotaxanes.

2021·6citations·K. Dikshit et al.·Soft matter

Soft matter

DOI: 10.1007/s10847-021-01068-4

Synthesis of cyclodextrin‐based radial polycatenane cyclized by amide bond and subsequent fabrication of water‐soluble derivatives

Cyclodextrin-based polycatenane can be synthesised via amide bond, leading to the synthesis of water-soluble derivatives for use in polycatenane-based materials.

2021·6citations·Kentato Morita et al.·Journal of Inclusion Phenomena and Macrocyclic Chemistry

Journal of Inclusion Phenomena and Macrocyclic Chemistry