2-Hydrazino-4-(5-nitro-2-furyl)thiazole, 2-(2, 2-dimethylhydrazino)-4-(5-nitro-2-furyl)thiazole, 2-hydrazino-4-(4-nitrophenyl)thiazole, and 2-hydrazino-4-(4-aminophenyl)thiazole were fed to female Sprague-Dawley rats, and all were found to be potent carcinogens. Each induced chiefly carcinomas of the mammary gland (32/35, 30/31, 27/34, 34/35, respectively), as well as a lower incidence of tumors of other organs. The carcinogenic relationship of these four compounds to formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide is discussed.

2-hydrazinothiazoles with nitrofuryl, nitrophenyl, or aminophenyl substituents in the 4-position are potent carcinogens, mainly inducing mammary gland carcinomas.

Paper

Comparative carcinogenicity in the rat of 2-hydrazinothiazoles with nitrofuryl, nitrophenyl, or aminophenyl substituents in the 4-position.

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