Paper

Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate derivatives: in vitro evaluation, cell cycle analysis and QSAR studies.

Published Dec 1, 2011 · Rui M. V. Abreu, I. Ferreira, R. Calhelha

European journal of medicinal chemistry

163

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Abstract

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In Vitro StudyHighly Cited

Study Snapshot

6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate derivatives show promising anti-hepatocellular carcinoma activity without hepatotoxicity, offering potential for future HCC therapy.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate derivatives: in vitro evaluation, cell cycle analysis and QSAR studies.

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