Paper
Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH.
Published Aug 1, 2018 · S. Nadtochiy, Yves T. Wang, K. Nehrke
Journal of molecular and cellular cardiology
Q1 SJR score
52
Citations
1
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Non-RCT
Animal StudyStudy Snapshot
NMN provides acute cardioprotection by stimulating glycolysis, with potential protective mechanisms involving enhanced ATP synthesis during ischemia and/or enhanced acidosis during reperfusion.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies
Pharmacological approaches show promising results in protecting against ischemia/reperfusion injury by modulating cell-surviving pathways, evading oxidative damage, protecting cell membrane integrity, and enhancing cell energetics.
2019·257citations·Ricardo O S Soares et al.·International Journal of Molecular Sciences
International Journal of Molecular Sciences
NAD+ in Aging: Molecular Mechanisms and Translational Implications.
NAD+ depletion during aging contributes to various chronic diseases, and interventions boosting NAD+ levels may slow aging and prevent age-related diseases.
2017·371citations·E. Fang et al.·Trends in molecular medicine
Trends in molecular medicine
Modulating NAD+ metabolism, from bench to bedside
Boosting NAD+ levels can improve mitochondrial homeostasis and enhance healthspan and lifespan by preventing aging and various diseases.
2017·182citations·E. Katsyuba et al.·The EMBO Journal
The EMBO Journal
Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation
There is no direct link between enzyme acetylation and 2-hydroxyglutarate production, suggesting no causal relationship between acetylation and enzyme activities.
2017·15citations·S. Nadtochiy et al.·bioRxiv
bioRxiv
Mitochondrial Sirtuins and Molecular Mechanisms of Aging.
Mitochondrial sirtuins (SIRT3-5) play a crucial role in aging and age-related pathologies by acting as stress sensors and regulating substrate clusters.
2017·249citations·Robert A. H. van de Ven et al.·Trends in molecular medicine
Trends in molecular medicine
Citations
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NAD-based therapies show promise in treating cardiovascular diseases, but challenges remain in understanding their mechanisms and implementing them in clinical trials.
2024·1citation·Matthew A. Walker et al.·Journal of molecular and cellular cardiology
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Mitochondrial unfolded protein response mechanism and its cardiovascular protective effects.
The mitochondrial unfolded protein response (UPR mt) plays a protective role against cardiovascular diseases by maintaining intra-protein homeostasis in response to cellular stress.
2024·2citations·Jinlan Deng et al.·Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Research progress on Sirtuins (SIRTs) family modulators.
Sirtuins modulators show potential in treating various diseases and maintaining physiological balance, with potential applications in cancer, autoimmune diseases, and cardiovascular disorders.
2024·7citations·Mingkai Chen et al.·Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
NADH: the redox sensor in aging-related disorders.
NADH plays a crucial role in maintaining redox homeostasis and energy metabolism, and its potential impact on aging-related disorders warrants further exploration in clinical settings.
2024·3citations·Giovanna Schiuma et al.·Antioxidants & redox signaling
Antioxidants & redox signaling