Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxicity in mice and glutamate toxicity in primary cultures of neurons.

doi:10.1016/s0022-3565(25)20954-5

Paper

Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxicity in mice and glutamate toxicity in primary cultures of neurons.

Published Oct 1, 1996 · M. Miñana, Carlos Hermenegildo, M. Llsansola

The Journal of pharmacology and experimental therapeutics

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61

Citations

1

Influential Citations

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Carnitine and choline derivatives with a trimethylamine group prevent ammonia toxicity in mice and glutamate neurotoxicity in primary neuronal cultures, supporting the idea that acute ammonia toxicity is mediated by activation of N-methyl-D-aspartate receptors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxicity in mice and glutamate toxicity in primary cultures of neurons.

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References

Citations

Betaine and related compounds: Chemistry, metabolism and role in mitigating heat stress in poultry.

Betaine, a multi-nutritional agent, can improve poultry performance, meat quality, and reduce heat stress by acting as an osmoprotectant, methionine-sparing, and antioxidant.

Expression of Matrix Metalloproteinase 9 in Oreochromis Niloticus Fish and Its Active Role in Initiation and Resolution of Ammonia

Ammonia stress in Oreochromis niloticus fish is mediated by MMP-9, which can be inhibited to reduce the impact of ammonia on fish health.

Gut Reactions: Breaking Down Xenobiotic–Microbiome Interactions

Gut microbiome influences drug metabolism and efficacy, presenting challenges in drug discovery and precision medicine.

Air-breathing and excretory nitrogen metabolism in fishes.

Ancient fishes had to develop strategies to deal with ammonia toxicity during water-land transition, as air-breathing fishes had to adapt to cope with ammonia toxicity during emersion.

Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota

Gut microbiota, particularly Enterobacteriaceae, can convert TMAO to TMA, which is then uptaken into the bloodstream and converted back to TMAO by host enzymes.

Changes of ammonia, urea contents and transaminase activity in the body during aerial exposure and ammonia loading in Chinese loach Paramisgurnus dabryanus

Chinese loach Paramisgurnus dabryanus can accumulate high levels of internal ammonia due to its high ammonia tolerance, and NH3 volatilization may be a potential ammonia detoxification strategy.

Neurotoxicity of Ammonia

Hyperammonemia, caused by abnormal liver function, significantly affects brain metabolism, astrocyte volume regulation, and mitochondrial functions, potentially underlining the pathological phenomena in hepatic encephalopathy.

Trimethylamine oxide accumulation as a function of depth in Hawaiian mid-water fishes

TMAO levels are strongly correlated with depth in Hawaiian mid-water fishes, with lipid content increasing with depth, contradicting previous studies.

To Break or to Brake Neuronal Network Accelerated by Ammonium Ions?

Ammonium ions accelerate neuronal network firing, potentially preventing acute ammonia neurotoxicity by activating inhibitory receptors and reinforcing negative feedback control.