Cascade Reaction of Arylboronic Acids and 2'-Cyano-biaryl-2-aldehyde N-Tosylhydrazones: Access to Functionalized 9-Amino-10-arylphenanthrenes.

doi:10.1021/acs.joc.8b02605

Paper

Cascade Reaction of Arylboronic Acids and 2'-Cyano-biaryl-2-aldehyde N-Tosylhydrazones: Access to Functionalized 9-Amino-10-arylphenanthrenes.

Published Dec 11, 2018 · Yueqiang Liu, Ling-Qi Chen, Zhong Wang

The Journal of organic chemistry

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28

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0

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Abstract

An efficient, general, and convenient protocol for the synthesis of functionalized 9-amino-10-arylphenanthrene derivatives using a catalyst-free cascade reaction of arylboronic acids and 2'-cyano-biaryl-2-aldehyde N-tosylhydrazones is described. The synthesis was carried out via simple experimental conditions using Na2CO3 in 1,4-dioxane as a solvent. Moreover, the 9-amino-10-arylphenanthrene compounds were also obtained on a gram scale and further derivatized to synthesize the fused phenanthrene derivatives.

Study Snapshot

This study presents a catalyst-free cascade reaction for the synthesis of functionalized 9-amino-10-arylphenanthrene derivatives using Na2CO3 in 1,4-dioxane, enabling further derivatization and fused phenanthrene derivatives.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Cascade Reaction of Arylboronic Acids and 2'-Cyano-biaryl-2-aldehyde N-Tosylhydrazones: Access to Functionalized 9-Amino-10-arylphenanthrenes.

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