Catalyst-free synthesis of 3-hydroxyimidazo[1,2-a]pyridine zwitterion derivatives via the three-component reaction of ethyl glyoxalate, 2-aminopyridines and cyclic 1,3-dicarbonyls

doi:10.1016/J.TETLET.2017.04.009

Paper

Catalyst-free synthesis of 3-hydroxyimidazo[1,2-a]pyridine zwitterion derivatives via the three-component reaction of ethyl glyoxalate, 2-aminopyridines and cyclic 1,3-dicarbonyls

Published May 10, 2017 · M. Ghandi, P. Moshtaghi, A. Abbasi

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3

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Abstract

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Study Snapshot

This reaction allows for the synthesis of 3-hydroxyimidazo[1,2-a]pyridine zwitterion derivatives without catalysts, making it a promising method for synthesis of organic compounds.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Catalyst-free synthesis of 3-hydroxyimidazo[1,2-a]pyridine zwitterion derivatives via the three-component reaction of ethyl glyoxalate, 2-aminopyridines and cyclic 1,3-dicarbonyls

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References

H2O2/DMSO-Promoted Regioselective Synthesis of 3,3'-Bisimidazopyridinylmethanes via Intermolecular Oxidative C(sp(2))-H Bond Activation of Imidazoheterocycles.

This study presents a novel, metal-free synthesis of 3,3'-bisimidazopyridinylmethanes using intermolecular oxidative C(sp(2))-H bond functionalization of imidazo[1,2-a]pyridines and dimethyl sulfoxide under

Synthesis of Indeno[1',2':4,5]imidazo[1,2-a]pyridin-11-ones and Chromeno[4',3':4,5]imidazo[1,2-a]pyridin-6-ones through Palladium-Catalyzed Cascade Reactions of 2-(2-Bromophenyl)imidazo[1,2-a]pyridines.

Palladium-catalyzed cascade reactions of 2-(2-bromophenyl)imidazo[1,2-a]pyridines enable efficient synthesis of indenone-imidazopyridine hybrids and chromenone-imidazopyridine hybrids.

CBr4 Mediated Oxidative C-N Bond Formation: Applied in the Synthesis of Imidazo[1,2-α]pyridines and Imidazo[1,2-α]pyrimidines.

CBr4-mediated oxidative carbon-nitrogen bond formation allows for the synthesis of complex imidazo[1,2-]pyridines and imidazo[1,2-]pyrimidines under mild, metal-free conditions.

Copper-Mediated Aerobic Oxidative Synthesis of 3-Bromo-imidazo[1,2-a]pyridines with Pyridines and Enamides.

Copper-mediated aerobic oxidative coupling allows for the one-pot synthesis of 3-bromo-imidazo[1,2-a]pyridines with pyridines and enamides under mild conditions.

Regioselective Fluorination of Imidazo[1,2-a]pyridines with Selectfluor in Aqueous Condition.

Selectfluor effectively synthesizes 3-fluorinated imidazo[1,2-a]pyridines in moderate to good yields in aqueous conditions, with moderate to good selectivity in the presence of DMAP.

Citations

One-pot synthesis, NMR, quantum chemical approach, molecular docking studies, drug-likeness and in-silico ADMET prediction of novel 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-(furan-2-yl)-4,5-diphenyl-1H-imidazole derivatives

The novel drug DDFDI, a hydroxyl chloroquine analogue, shows potential as a better antiviral agent for treating SARS-CoV-2 infections.

Synthesis, spectral characterization, crystal examination, DFT method and molecular docking studies of 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-(thiophen-2-yl)-1H-phenanthro[9,10-d]imidazole

The novel compound DDTP, a potential non-ligand-obsolete material, was synthesized in one pot reaction and shows promising stability and biological activity against standard drugs.