Catechol-O-methyltransferase. II. A new class of inhibitors of catechol-o-methyltransferase; 3,5-dihydroxy-4-methoxybenzoic acid and related compounds.

doi:10.1016/s0022-3565(25)28595-0

Paper

Catechol-O-methyltransferase. II. A new class of inhibitors of catechol-o-methyltransferase; 3,5-dihydroxy-4-methoxybenzoic acid and related compounds.

Published Jul 1, 1970 · B. Nikodejevic, S. Senoh, J. Daly

The Journal of pharmacology and experimental therapeutics

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145

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Abstract

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In Vitro Study

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Study Snapshot

The benzoic acid derivatives, which are nontoxic and effectively inhibit catechol-O-methyltransferase, show a complex relationship with magnesium ion concentration and enzyme activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Catechol-O-methyltransferase. II. A new class of inhibitors of catechol-o-methyltransferase; 3,5-dihydroxy-4-methoxybenzoic acid and related compounds.

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References

Citations

Inhibition of catechol-O-methyltransferase in the cynomolgus monkey by opicapone after acute and repeated administration

Opicapone effectively inhibits COMT in cynomolgus monkeys, improving levodopa bioavailability in Parkinson's disease patients, while rapidly eliminating it from plasma after 14 days of administration.

Neurochemical and Behavioral Features in Genetic Absence Epilepsy and in Acutely Induced Absence Seizures

Genetic absence epilepsy is associated with a deficiency in dopaminergic system activity, affecting emotional positive states, learning, and memory processes.

Gestational Restraint Stress and the Developing Dopaminergic System: An Overview

Prenatal stress negatively impacts fetal brain development, leading to anxiety, altered sexual function, and increased drug use in rats, with potential links to neurological disorders in humans.

On the determination of catechol-O-methyltransferase activity in tissue homogenates.

The present fluorimetric method for determining catechol-O-methyltransferase activity in tissue homogenates is suitable for low enzyme activity tissues like brain.

A universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferases.

This sensitive and homogeneous assay effectively detects methyltransferase activity, making it suitable for screening compounds for inhibitors of methyltransferase activity.

Antiangiogenic activity of 4-O-methylgallic acid from Canavalia gladiata, a dietary legume.

4-O-methylgallic acid (4-OMGA) from Canavalia gladiata seeds shows potential as an antiangiogenic agent, inhibiting endothelial cell invasion and tube formation without cytotoxicity.

A colormetric assay for catechol-O-methyltransferase.

This study developed a sensitive HPLC assay method using visible wavelength light detection for detecting catechol-O-methyltransferase (COMT) products, enabling the determination of regioisomeric methylated products without pre-preparation of assay samples.

Separation methods for catechol O-methyltransferase activity assay: physiological and pathophysiological relevance.

COMT activity analysis is useful for studying basic properties of COMT and its relation to various diseases, and has been applied clinically for Parkinson's disease treatment.

Purification methods of mammalian catechol-O-methyltransferases.

Purification strategies for rat and human S-COMT polypeptides in Escherichia coli and baculovirus-infected insect cells have enhanced the development of more potent COMT inhibitors.