Cell culture replication of herpes simplex virus and, or human cytomegalovirus is inhibited by 3,7-dialkoxylated, 1-hydroxyacridone derivatives.

doi:10.1016/S0166-3542(03)00106-2

Paper

DOI: 10.1016/S0166-3542(03)00106-2

Cell culture replication of herpes simplex virus and, or human cytomegalovirus is inhibited by 3,7-dialkoxylated, 1-hydroxyacridone derivatives.

Published Aug 1, 2003 · C. Lowden, K. Bastow

Antiviral research

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

3,7-dialkoxylated 1-hydroxyacridone derivatives effectively inhibit herpes simplex virus and human cytomegalovirus replication, offering potential medicinal interest.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1016/S0166-3542(02)00193-6

Direct antiviral effect of cycloferon (10-carboxymethyl-9-acridanone) against adenovirus type 6 in vitro.

Cycloferon (CMA) shows direct antiviral activity against adenovirus type 6 in vitro, reducing the virus's ability to generate infectious progeny and suppressing late stages of viral cycle in infected cells.

2003·24citations·V. Zarubaev et al.·Antiviral research

Antiviral research

DOI: 10.1002/0471266949.BMC082

Antiviral Agents, DNA

Nucleoside analogs are the most successful antiviral tools, targeting polymerases of herpesviruses and hepatitis virus B, but other viral targets are becoming more important as resistance to current drugs increases.

2003·2citations·T. Middleton et al.·Burger's Medicinal Chemistry and Drug Discovery

Burger's Medicinal Chemistry and Drug Discovery

DOI: 10.1016/S0166-3542(01)00203-0

The antiviral agent 5-chloro-1,3-dihydroxyacridone interferes with assembly and maturation of herpes simplex virus.

5-chloro-1,3-dihydroxyacridone inhibits herpes simplex virus assembly and maturation, resulting in reduced levels of capsids and encapsidated DNA.

2002·32citations·P. Akanitapichat et al.·Antiviral research

Antiviral research

DOI: 10.1021/JM000033P

Benzothiadiazine dioxide dibenzyl derivatives as potent human cytomegalovirus inhibitors: synthesis and comparative molecular field analysis.

Benzothiadiazine dioxide dibenzyl derivatives show potent human cytomegalovirus inhibitory activity, with IC(50) values between 2.5 and 50 microM, and structural and electrostatic features influencing their antiviral activity.

2000·24citations·A. Martínez et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.1016/S0166-3542(00)00068-1

1,3-Dihydroxyacridone derivatives as inhibitors of herpes virus replication.

1,3-dihydroxyacridone derivatives show potential as selective inhibitors of herpes virus replication, suggesting DNA topoisomerase II may not be the critical antiviral target.

2000·24citations·P. Akanitapichat et al.·Antiviral research

Antiviral research

Citations

DOI: 10.1016/j.bioorg.2023.106526

Syntheses and evaluation of acridone derivatives as anticancer agents targeting Kras promoter i-motif structure.

C4, a novel acridone derivative, shows potent anticancer activity against Hep-G2 cells by targeting the Kras promoter i-motif and inducing apoptosis through mitochondrial dysfunction.

2023·3citations·Zuzhuang Wei et al.·Bioorganic chemistry

Bioorganic chemistry

DOI: 10.1134/S1070428017100165

3H-Benzo[a]imidazo[4,5-j]acridine as a new fluorescent heterocyclic system: synthesis, spectral studies, and quantum chemical investigation

3H-benzo[a]imidazo[4,5-j]acridine is a new fluorescent heterocyclic system with high molar absorption coefficients and fluorescence quantum yields, surpassing well-known dyes like fluorescein.

2017·1citation·H. Alipoor et al.·Russian Journal of Organic Chemistry

Russian Journal of Organic Chemistry

DOI: 10.3184/146867816X14720534560565

Theoretical Investigation on the Kinetics and Mechanism of the Synthesis of Fluorescent 3,8-Disubstituted-3H-Imidazo [4,5-a] Acridine-11-Carbonitriles

Intramural electrophilic aromatic substitution is the most plausible mechanism for the synthesis of fluorescent 3,8-Disubstituted-3H-Imidazo[4,5-a] Acridine-11-Carbonitriles, with electron-donor substituents reducing the activation energy for formation of the

2016·7citations·Fatemeh Zonozi et al.·Progress in Reaction Kinetics and Mechanism

Progress in Reaction Kinetics and Mechanism

DOI: 10.1016/j.jphotobiol.2016.05.028

Potent acetylcholinesterase inhibitors: Synthesis, biological assay and docking study of nitro acridone derivatives.

1,7-Dinitroacridone is the most potent acetylcholinesterase inhibitor and shows antioxidant activity, with good agreement with in vitro experiments and docking study results.

2016·25citations·M. Parveen et al.·Journal of photochemistry and photobiology. B, Biology

Journal of photochemistry and photobiology. B, Biology

DOI: 10.1007/s11094-016-1356-7

Human Serum Albumin Interactions with Bioactive 3H-Imidazo[4,5-A]Acridin-11(6H)-Ones Studied by Fluorescence Spectroscopy

3H-imidazo[4,5-a]acridin-11(6H)-ones show a 1:1 interaction with human serum albumin, suggesting potential antibacterial activity.

2016·3citations·Parvin Tavanaei et al.·Pharmaceutical Chemistry Journal

Pharmaceutical Chemistry Journal