Further characterization of the cardiovascular effects of the dopamine beta-hydroxylase inhibitor SK&F 102698 in conscious hypertensive rats.

doi:10.1016/s0022-3565(25)19994-1

Paper

Further characterization of the cardiovascular effects of the dopamine beta-hydroxylase inhibitor SK&F 102698 in conscious hypertensive rats.

Published Oct 1, 1988 · E. Ohlstein, L. Kruse, Mildred Ezekiel

The Journal of pharmacology and experimental therapeutics

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4

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

The dopamine beta-hydroxylase inhibitor SK&F 102698 reduces blood pressure in hypertensive rats through both peripheral and central mechanisms, suggesting central dopamine receptors contribute to blood pressure control.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Further characterization of the cardiovascular effects of the dopamine beta-hydroxylase inhibitor SK&F 102698 in conscious hypertensive rats.

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References

Citations

Regulation of blood pressure with calcium-dependent dopamine synthesizing system in the brain and its related phenomena

Calcium ions play two separate roles in blood pressure regulation: one to reduce it through a central dopamine-synthesizing system and another to increase it through an intracellular mechanism in the peripheral vasculature.

Action of beta-phenylethylamine and related amines on nigrostriatal dopamine neurotransmission.

At low doses, -phenylethylamine stimulates dopamine release from the cytoplasmic pool and acts as a dopamine receptor agonist with rapid and brief action.

Decrease of central dopamine level in the adult spontaneously hypertensive rats related to the calcium metabolism disorder

Decreased serum calcium levels in spontaneously hypertensive rats lead to decreased central dopamine synthesis, leading to an increase in blood pressure through cerebral dopaminergic neurons and peripheral sympathetic nerves.