[Relationship between the chemical structure and anticonvulsant activity of 3-hydroxypyridine derivatives].

Paper

[Relationship between the chemical structure and anticonvulsant activity of 3-hydroxypyridine derivatives].

Published 1986 · Voronina Ta, Smirnov Ld, Aliev Ai

Farmakologiia i toksikologiia

UNKNOWN SJR score

1

Citations

0

Influential Citations

Semantic Scholar

Abstract

It was revealed in experiments on mice, that 3-hydroxypyridine derivatives possess marked anticonvulsive activity, especially in convulsions induced by GABA-ergic substances, less in corasol, maximal electroshock and strychnine induced ones. The anticonvulsive activity in the rows of 2-substituted and 2.6-disubstituted derivatives of 3-hydroxypyridine gets increased due to the introduction of larger in volume alkyl substitutes into the 2nd molecule position. Among the 2,6-disubstituted 3-hydroxypyridine derivatives, agents were revealed that are able to enhance hyperkinesis induced by 5-hydroxytryptophan.

Non-RCT

Animal Study

Study Snapshot

3-hydroxypyridine derivatives show marked anticonvulsive activity, particularly in GABA-ergic-induced convulsions, with 2,6-disubstituted derivatives enhancing hyperkinesis induced by 5-hydroxytryptophan.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

[Relationship between the chemical structure and anticonvulsant activity of 3-hydroxypyridine derivatives].

Sign up to use Study Snapshot

References

Citations

Research and development of 2-ethyl-6-methyl-3-oxypyridine succinate nano-form for the treatment of epilepsy

The nano-drug, based on 2-ethyl-6-methyl-3-oxypyridine succinate, effectively reduces secondary generalized clonic-tonic seizures by 7.8 times, 10-fold animal mortality, and diminishes seizure manifestations during epileptic status.