Chloroquine and hydroxychloroquine in antitumor therapies based on related-autophagy mechanisms.

doi:10.1016/j.phrs.2021.105582

Paper

Chloroquine and hydroxychloroquine in antitumor therapies based on related-autophagy mechanisms.

Published Mar 25, 2021 · P. Ferreira, Rayran Walter Ramos de Sousa, José Roberto de Oliveira Ferreira

Pharmacological research

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87

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Abstract

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Study Snapshot

Chloroquine and hydroxychloroquine enhance antitumor effects by disrupting autophagy and sensitizing chemotherapy, but may develop chemo or radioresistance due to their related-MDR genes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Chloroquine and hydroxychloroquine in antitumor therapies based on related-autophagy mechanisms.

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