Paper
Chromone studies. Part 13. Synthesis and electron-impact mass spectrometric studies of 5-hydroxy-2-isopropyl-7-methoxychromone, a constituent of the medicinal plant Baeckea frutescens, and side-chain analogues.
Published Aug 1, 2003 · C. A. Gray, P. Kaye, Aloysius T. Nchinda
Journal of natural products
18
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Abstract
5-Hydroxy-2-isopropyl-7-methoxychromone (1d), a chromone constituent isolated from the aerial parts of Baeckea frutescens, and four analogues (1a-c and 1e), all of which exhibit toxicity to the brine shrimp Artemia salina, have been prepared from 2',4',6'-trihydroxyacetophenone. High-resolution mass spectrometric analysis has permitted elucidation of the fragmentation patterns exhibited by these systems following electron-impact ionization.
5-Hydroxy-2-isopropyl-7-methoxychromone and its analogues from Baeckea frutescens exhibit toxicity to brine shrimp Artemia salina, suggesting potential as a pharmaceutical agent.
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