Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity

doi:10.3390/molecules191219292

Paper

Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity

Published Nov 25, 2014 · DOI · J. Guzman

Molecules

349

Citations

8

Influential Citations

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Abstract

Antimicrobial natural preparations involving cinnamon, storax and propolis have been long used topically for treating infections. Cinnamic acids and related molecules are partly responsible for the therapeutic effects observed in these preparations. Most of the cinnamic acids, their esters, amides, aldehydes and alcohols, show significant growth inhibition against one or several bacterial and fungal species. Of particular interest is the potent antitubercular activity observed for some of these cinnamic derivatives, which may be amenable as future drugs for treating tuberculosis. This review intends to summarize the literature data on the antimicrobial activity of the natural cinnamic acids and related derivatives. In addition, selected hybrids between cinnamic acids and biologically active scaffolds with antimicrobial activity were also included. A comprehensive literature search was performed collating the minimum inhibitory concentration (MIC) of each cinnamic acid or derivative against the reported microorganisms. The MIC data allows the relative comparison between series of molecules and the derivation of structure-activity relationships.

Literature ReviewHighly Cited

Study Snapshot

Natural cinnamic acids and their derivatives show significant antimicrobial activity against various bacteria and fungal species, with potential as future drugs for treating tuberculosis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity

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