Clausine Z, a new carbazole alkaloid from Clausena excavata with inhibitory activity on CDK5.

doi:10.1002/CHIN.200550185

Paper

Clausine Z, a new carbazole alkaloid from Clausena excavata with inhibitory activity on CDK5.

Published Aug 1, 2005 · O. Potterat, C. Puder, W. Bolek

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Abstract

A new carbazole alkaloid, named clausine Z, has been isolated from the stems and leaves of Clausena excavata Burm. (Rutaceae). Its structure was established by spectroscopic methods. The compound exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro.

Study Snapshot

Clausine Z, a new carbazole alkaloid from Clausena excavata, shows inhibitory activity against CDK5 and protective effects on cerebellar granule neurons in vitro.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Clausine Z, a new carbazole alkaloid from Clausena excavata with inhibitory activity on CDK5.

References

Citations

Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases

Phyto-carbazole alkaloids from the Rutaceae family show potential as neuroprotective agents against neurodegenerative diseases, potentially benefiting from their multitarget approaches.

Phytocarbazoles: alkaloids with great structural diversity and pronounced biological activities

Phytocarbazoles, derived from 3-methylcarbazole, show great structural diversity and diverse biological activities, including antimicrobial, antiprotozoal, and anti-HIV properties, and potential for inhibiting tumor growth in vivo.

A review of traditional uses, phytochemical and pharmacological aspects of selected members of Clausena genus (Rutaceae)

Clausena genus members show potential as medicinal plants due to their phytochemical and pharmacological properties, including anti-inflammatory, antiviral, antioxidant, cytotoxic, and antibacterial activities.

Antibacterial carbazole alkaloids from Clausena harmandiana twigs.

Compounds 14 and 5 from Clausena harmandiana twigs show strong antibacterial activity against MRSA SK1, while compound 6 shows higher antibacterial activity than vancomycin.

Clausena excavata Burm. f.(Rutaceae): A review of its traditional uses, pharmacological and phytoche

Clausena excavata (Rutaceae) is a rich source of medicinal natural products with potential anticancer, immunomodulatory, anti-HIV-1, antioxidant, and pharmacological activities.

Interplay between the p53 tumor suppressor protein family and Cdk5

Cdk5 plays a crucial role in cell cycle progression and neuronal death, and its inhibition may be beneficial in neurodegenerative diseases.

Neuronal activity

Interpreting neurophysiological research results in the context of the organism's functioning improves understanding of electric neuronal activity mechanisms.