Paper
Cobalt- and iron-catalyzed redox condensation of o-substituted nitrobenzenes with alkylamines: a step- and redox-economical synthesis of diazaheterocycles.
Published Nov 14, 2013 · T. Nguyen, Julie le Bescont, L. Ermolenko
Organic letters
Q1 SJR score
103
Citations
2
Influential Citations
Abstract
A wide variety of functionalized 2-aryl benzimidazoles can be prepared by a solvent-free cobalt- or iron-catalyzed redox condensation of 2-nitroanilines and benzylamines. The cascade including benzylamine oxidation, nitro reduction, condensation, and aromatization occurs without any added reducing or oxidizing agent. The method can be extended to other alkylamines as reducing components or 2-nitrobenzamides as oxidizing components when using an iron/sulfur catalyst to afford various diazaheterocycles.
Highly CitedStudy Snapshot
This study presents a solvent-free, redox-economical method for preparing functionalized 2-aryl benzimidazoles using 2-nitroanilines and benzylamines, with potential applications in various diazaheterocycles.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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N-CHLOROSUCCINIMIDE/SODIUM HYDROXIDE-MEDIATED SYNTHESIS OF BENZIMIDAZOLES FROM AMIDINES UNDER MILD CONDITIONS (Dedicated to Professor Dr. Ei-ichi Negishi on the occasion of his 77th birthday)
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