Paper
Cold urticaria.
Published 1972 · DOI · W. A. Akers
California medicine
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Abstract
UPON EXPOSURE TO COID, patients with acquired cold urticaria develop hives and pruritus, and exhibit signs of systemic histamine release such as nausea, vomiting, headache, flushing, tachycardia and syncope. Application of an ice cube to skin for 2 to 3 minutes followed by re-warming usually produces a localized hive in these patients. However, some patients may have a negative ice cube test, but still develop urticaria when total body cooling occurs from exposure to cold air or water. A personal atopic history of asthma, hayfever, or dermatitis is present in 30 to 50 percent of patients, and many have a passive transfer factor associated with IgE skin sensitizing antibodies. Cryofibrinogen, cryoglobulins, cold hemolysins, and cold agglutinins may also induce cold urticaria and should be searched for. Treatment with antihistamines such as methdilazine (Tacaryl®) and cyproheptadine (Periactin®, Dronactin®l) is helpful in some cases. WILLIAM A. AKERS, M.D.
Cold urticaria develops hives and pruritus, and may be induced by cold air or water, with a history of atopic conditions and potential allergens.
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