Paper

Combination treatment of acute myeloid leukemia cells with DNMT and HDAC inhibitors: predominant synergistic gene downregulation associated with gene body demethylation

Published Oct 12, 2018 · Nadja Blagitko-Dorfs, P. Schlosser, G. Greve

Leukemia

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Abstract

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In Vitro StudyHighly Cited

Study Snapshot

Combining DNMT and HDAC inhibitors in acute myeloid leukemia cells leads to synergistic gene downregulation, predominantly associated with gene body demethylation and changes in acH3K9/27.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Combination treatment of acute myeloid leukemia cells with DNMT and HDAC inhibitors: predominant synergistic gene downregulation associated with gene body demethylation

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