Combined directed ortho and remote metalation-cross-coupling strategies. General method for benzo[a]carbazoles and the synthesis of an unnamed indolo[2,3-a]carbazole alkaloid.

doi:10.1021/OL049780X

Paper

Combined directed ortho and remote metalation-cross-coupling strategies. General method for benzo[a]carbazoles and the synthesis of an unnamed indolo[2,3-a]carbazole alkaloid.

Published Jun 11, 2004 · Xiongwei Cai, V. Snieckus

Organic letters

Q1 SJR score

80

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

[reaction: see text] An efficient route to benzo[a]carbazoles via a metalation-cross-coupling sequence has been demonstrated and its application to the synthesis of the antitumor and antiviral alkaloid 6-cyano-5-methoxy-12-methylindolo[2,3-a]carbazole has been achieved.

Highly Cited

Study Snapshot

This study demonstrates an efficient route to benzo[a]carbazoles and the synthesis of the antitumor and antiviral alkaloid 6-cyano-5-methoxy-12-methylindolo[2,3-a]carbazole using a metalation-cross-coupling

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Combined directed ortho and remote metalation-cross-coupling strategies. General method for benzo[a]carbazoles and the synthesis of an unnamed indolo[2,3-a]carbazole alkaloid.

Sign up to use Study Snapshot

References

The directed ortho metalation - palladium catalyzed cross coupling connection. A general regiospecific route to 9-phenanthrols and phenanthrenes. Exploratory further metalation

This study presents a new regiospecific route to 9-phenanthrols and phenanthrenes using directed ortho metalation, Suzuki-Miyaura cross coupling, and LDA-mediated remote metalation.

Synthesis of Homofascaplysin C and Indolo[2,3-a]carbazole from Ditryptophans

Homofascaplysin C and indolo[2,3-a]carbazole can be synthesized from ditryptophans, offering potential for new anti-inflammatory and anti-tumor agents.

Cytotoxic, antiviral indolocarbazoles from a blue-green alga belonging to the Nostocaceae.

The compounds from Nostoc sphaericum EX-5-1 show strong cytotoxicity and antiviral activity against HSV II, with weak cytotoxicity against KB and LoVo human carcinoma cell lines.

The First Syntheses of Antiviral, Cytotoxic 6-Cyano-5-methoxy- and -12-methylindolo[2,3-a]carbazoles, and Related Indolo[2,3-a]carbazoles from Indigo

The first synthetic total syntheses of antiviral and cytotoxic 6-cyano-5-methoxy- and -12-methylindolo[2,3-a]carbazoles from indigo were achieved in five and six steps, respectively.

Citations