Comparative study of the trypanocidal activity of the methyl 1-nitrophenyl-1,2,3,4-9H-tetrahydro-beta-carboline-3-carboxylate derivatives and benznidazole using theoretical calculations and cyclic voltammetry.

doi:10.1016/j.ejmech.2008.03.044

Paper

DOI: 10.1016/j.ejmech.2008.03.044

Comparative study of the trypanocidal activity of the methyl 1-nitrophenyl-1,2,3,4-9H-tetrahydro-beta-carboline-3-carboxylate derivatives and benznidazole using theoretical calculations and cyclic voltammetry.

Published Apr 1, 2009 · L. Tonin, V. A. Barbosa, C. C. Bocca

European journal of medicinal chemistry

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Abstract

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In Vitro Study

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The trans-methyl 1-(m-nitro)phenyl-1,2,3,4-9H-tetrahydro-beta-carboline-3-carboxylate (3b) shows significant trypanocidal activity against Trypanosoma cruzi epimastigote forms, with a

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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