Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet

doi:10.1038/sj.ejcn.1601083

Paper

DOI: 10.1038/sj.ejcn.1601083

Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet

Published Sep 1, 2000 · M. Hallikainen, E. Sarkkinen, H. Gylling

European Journal of Clinical Nutrition

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255

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Abstract

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Study Snapshot

STAEST and STEEST margarines both significantly and equally reduced serum total and LDL cholesterol concentrations as part of a low-fat diet.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

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Plant stanol esters affect serum cholesterol concentrations of hypercholesterolemic men and women in a dose-dependent manner.

Plant stanol esters significantly reduce serum total and LDL cholesterol levels with a 1.6-g dose, and increasing the dose from 2.4 to 3.2 g does not provide clinically important additional effect.

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The Journal of nutrition

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Effects of low-fat stanol ester enriched margarines on concentrations of serum carotenoids in subjects with elevated serum cholesterol concentrations

Low-fat stanol ester margarines have little effect on serum concentrations of -, -, or +-carotene, or lycopene in hypercholesterolaemic subjects.

1999·77citations·M. Hallikainen et al.·European Journal of Clinical Nutrition

European Journal of Clinical Nutrition

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Retinol, vitamin D, carotenes and alpha-tocopherol in serum of a moderately hypercholesterolemic population consuming sitostanol ester margarine.

Sitostanol ester margarine lowers serum cholesterol without affecting vitamin D and retinol levels, but reduces serum -carotene levels, suggesting a link between cholesterol absorption and -tocopherol and carotenes.

1999·94citations·H. Gylling et al.·Atherosclerosis

Atherosclerosis

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Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men.

Adding blended phytosterols to a prudent North American diet improves plasma LDL-cholesterol concentrations without significantly changing endogenous cholesterol synthesis in hypercholesterolemic men.

1999·263citations·P. Jones et al.·The American journal of clinical nutrition

The American journal of clinical nutrition

DOI: 10.1016/S0026-0495(99)90053-7

Cholesterol reduction by different plant stanol mixtures and with variable fat intake.

Changing the campestanol to sitostanol ratio in margarine and butter similarly decreased cholesterol absorption, LDL cholesterol, and the LDL HDL cholesterol ratio, making serum lipids less atherogenic.

1999·188citations·H. Gylling et al.·Metabolism: clinical and experimental

Metabolism: clinical and experimental

Citations

DOI: 10.1080/1354750X.2022.2051072

Salvia hispanica L. seeds extract alleviate encephalopathy in streptozotocin-induced diabetes in rats: role of oxidative stress, neurotransmitters, DNA and histological indices

Chia seeds extract effectively reduces neurodegeneration in streptozotocin-induced diabetes in rats, potentially offering a new dietary supplement against diabetic encephalopathy.

2022·5citations·A. El-Feky et al.·Biomarkers

Biomarkers

DOI: 10.1016/j.jff.2021.104751

Gene-diet interaction in plasma lipid response to plant sterols and stanols: A review of clinical trials

Genetic factors, particularly the CYP7A1 c. 204 A > C variant, influence the plasma cholesterol reduction after plant sterol and stanol intake.

2021·5citations·Mussa Makran et al.·Journal of Functional Foods

Journal of Functional Foods

DOI: 10.1038/s41430-019-0504-z

Phytosterol compositions of enriched products influence their cholesterol-lowering efficacy: a meta-analysis of randomized controlled trials

Phytosterol products with higher sitosterol plus sitostanol proportions may have superior cholesterol-lowering potential than those with lower proportions.

2019·19citations·Jie Ying et al.·European Journal of Clinical Nutrition

European Journal of Clinical Nutrition

DOI: 10.15829/1728-8800-2019-3-5-10

The role of plant stanols in the primary prevention of hypercholesterolemia in patients with arterial hypertension

Plant stanols significantly reduce total and LDL cholesterol levels in patients with arterial hypertension, reducing their risk of atherosclerosis from 4% to 3.1% compared to a healthy diet alone.

2019·0citations·A. Safaryan et al.·Cardiovascular Therapy and Prevention

Cardiovascular Therapy and Prevention

DOI: 10.1002/ptr.6319

Possible anti‐obesity effects of phytosterols and phytostanols supplementation in humans: A systematic review and dose–response meta‐analysis of randomized controlled trials

Phytosterols and phytostanols supplementation may have anti-obesity effects, but only on BMI, with factors like BMI, hyperlipidemia, and dose and duration playing a role.

2019·29citations·Ehsan Ghaedi et al.·Phytotherapy Research

Phytotherapy Research