Abstract2-Aminomethylphenylacetic acid is an important intermediate of ceforanide, and this article compared two different protecting agents for protecting the amino group in 2-aminomethylphenylacetic acid by BOC (Di-tert butyl dicarbonate) or acetacetic ester, and compared the deprotection condition. The yield was higher when BOC was used as protecting agent, but when it was deprotected, it was more difficult than when acetacetic ester was used as protecting agent.

BOC protects the amino group in 2-aminomethylphenylacetic acid more effectively, but deprotection is more difficult than with acetacetic ester.

Paper

The comparison of protecting methods to the amino group in 2-Aminomethylphenylacetic acid

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