Complexation with β-cyclodextrin enhances apoptosis-mediated cytotoxic effect of harman in chemoresistant BRAF-mutated melanoma cells.

doi:10.1016/j.ejps.2020.105353

Paper

Complexation with β-cyclodextrin enhances apoptosis-mediated cytotoxic effect of harman in chemoresistant BRAF-mutated melanoma cells.

Published Apr 22, 2020 · Christiane Adrielly Alves Ferraz, R. G. O. Junior, A. D. de Oliveira

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

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8

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Abstract

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In Vitro Study

Study Snapshot

Complexation of harman with -cyclodextrin improves its bioavailability and cytotoxic effect in chemoresistant melanoma cells, potentially enhancing its antimelanoma activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Complexation with β-cyclodextrin enhances apoptosis-mediated cytotoxic effect of harman in chemoresistant BRAF-mutated melanoma cells.

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