Summary:  Purpose: Zonisamide (ZNS) and acetazolamide (AZM) are two antiepileptic drugs (AEDs) that differ in clinical efficacy. To elucidate the mechanisms of action of these compounds, we investigated their therapeutic and prophylactic effects in rats by using a kindling model of partial epilepsy.

Zonisamide and acetazolamide show different therapeutic and prophylactic effects on amygdaloid kindling in rats with partial epilepsy, suggesting different mechanisms of action.

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Contrasting Effects of Zonisamide and Acetazolamide on Amygdaloid Kindling in Rats

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