A Convenient Method of Synthesis of Bis-Indolylmethanes: Indium Trichloride Catalyzed Reactions of Indole with Aldehydes and Schiff's Bases

doi:10.1080/00397910008087197

Paper

DOI: 10.1080/00397910008087197

A Convenient Method of Synthesis of Bis-Indolylmethanes: Indium Trichloride Catalyzed Reactions of Indole with Aldehydes and Schiff's Bases

Published Apr 1, 2000 · Govindarajulu Babu, N. Sridhar, P. Perumal

Synthetic Communications

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160

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Abstract

Abstract Anhydrous indium trichloride (InCl3) is found to catalyze the electrophilic substitution reaction of indole with aromatic aldehydes and Schiff's bases which resulted in an efficient synthesis of bis-indolylmethanes in good to excellent yield.

Highly Cited

Study Snapshot

Indium trichloride catalyzes the efficient synthesis of bis-indolylmethanes with good to excellent yield, making it a convenient method for efficient synthesis of bis-indolylmethanes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1016/S0040-4039(98)00397-9

Convenient synthesis of pyrano[3,2-c]quinolines and indeno[2,1-c] quinolines by imino Diels-Alder reactions

Imino Diels-Alder reactions with anhydrous indium trichloride efficiently synthesize pyrano[3,2-c]quinolines and indeno[2,1-c] quinolines, leading to efficient synthesis of phenanthridine derivatives.

1998·108citations·G. Babu et al.·Tetrahedron Letters

Tetrahedron Letters

DOI: 10.1016/S0040-4020(97)10370-2

Indium trichloride (InCl3)catalyzed imino Diels-Alder reactions: An efficient synthesis of cyclopentaquinolines, azabicyclooctanones and azabicyclononanones

Indium trichloride (InCl3) catalyzes imino Diels-Alder reactions, enabling the facile synthesis of cyclopentaquinolines, azabicyclooctanones, and previously unreported azabicyclononanone

1998·63citations·G. Babu et al.·Tetrahedron

Tetrahedron

DOI: 10.1016/S0040-4039(97)01060-5

Imino Diels-Alder reactions catalyzed by indium trichloride (InCl3). Facile synthesis of quinoline and phenanthridinone derivatives

Indium trichloride catalyzes imino Diels-Alder reactions, leading to facile synthesis of quinoline derivatives and a previously unreported series of phenanthridinones.

1997·79citations·G. Babu et al.·Tetrahedron Letters

Tetrahedron Letters

DOI: 10.1246/CL.1991.1059

The Catalytic Friedel-Crafts Acylation Reaction Using a Catalyst Generated from GaCl3 and a Silver Salt.

The catalyst, made from GaCl3 and a silver salt, effectively speeds up the Friedel-Crafts acylation reaction, yielding aromatic ketones in high yields.

1991·25citations·T. Mukaiyama et al.·Chemistry Letters

Chemistry Letters

DOI: 10.1039/P19800000553

Lewis-acid-induced electrophilic substitution in indoles with acetone. Part 2

The electrophilic substitution reaction of indole with acetone in the presence of boron trifluoride produces dimer II, a monoclinic crystal with space group Cc and a refined structure.

1980·69citations·A. Chatterjee et al.·Journal of The Chemical Society-perkin Transactions 1

Journal of The Chemical Society-perkin Transactions 1

DOI: 10.1246/CL.1991.1059

The Catalytic Friedel-Crafts Acylation Reaction Using a Catalyst Generated from GaCl3 and a Silver Salt.

The catalyst, made from GaCl3 and a silver salt, effectively speeds up the Friedel-Crafts acylation reaction, yielding aromatic ketones in high yields.

1991·26citations·Teruaki Mukaiyama et al.·Chemistry Letters

Chemistry Letters

Citations

DOI: 10.1016/j.bmcl.2025.130132

Zirconium oxide nano-catalyzed bis(indolyl)methanes: A sustainable route to anticancer therapies.

ZrO2 nanoparticles catalyzed bis(indolyl)methanes show potential as promising anticancer agents with exceptional potency and fewer side effects compared to standard agents like sorafenib.

2025·0citations·Komal Rathi et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

DOI: 10.1002/slct.202305019

Exploring Untouched Variant of Bis(2‐methyl‐1H‐indol‐3‐yl)methane: Enhances Chemo and Mono‐Selectivity

The newly synthesized compound 4(bis(2methyl-1H-indol-3yl)methyl)-3bromophenol f) enhances chemo and mono-selectivity by boosting aldehyde reactivity via electrophilic activation.

2024·0citations·Ravikumar Merneedi et al.·ChemistrySelect

ChemistrySelect

DOI: 10.1007/s13738-024-03038-2

Ruthenium-exchanged montmorillonite as an efficient and reusable catalyst for the synthesis of bis(indolyl)methanes

Ruthenium-exchanged montmorillonite is an efficient and reusable catalyst for the synthesis of bis(indolyl)methanes, offering minimal reaction times, solvent-free conditions, and potential for catalyst recyclability.

2024·0citations·Sam Takbiri et al.·Journal of the Iranian Chemical Society

Journal of the Iranian Chemical Society

DOI: 10.1016/j.apcata.2023.119505

Novel acidic ionic liquid [BEMIM][HSO4]: A highly efficient and recyclable catalyst for the synthesis of bis-indolyl methane derivatives

The novel acidic ionic liquid [BEMIM][HSO4] is a highly efficient and recyclable catalyst for the synthesis of bis-indolyl methane derivatives at ambient temperature, with minimal loss of activity after five runs.

2023·9citations·Rajeshwari Athavale et al.·Applied Catalysis A: General

Applied Catalysis A: General

DOI: 10.1016/j.poly.2023.116584

Development of phosphotungstic acid immobilized amine-grafted graphene oxide as heterogeneous catalyst for synthesis of bis(indolyl)methane derivatives

Phosphotungstic acid immobilized on amine-grafted graphene oxide is a sustainable, highly effective catalyst for the synthesis of bis(indolyl)methane derivatives, with potential pharmaceutical applications.

2023·4citations·Dulu Brahma et al.·Polyhedron

Polyhedron