A mild, efficient, one-pot protocol for the synthesis of indazole-3(2H)-ones via cyclization of nitro-aryl substrates through low-valent titanium reagent has been described. The method used Triethylamine (TEA) to control pH. Particularly, 2-aminobenzonitriles were synthesized by one step easily. The mechanistic course of the reaction suggests the involvement of an anion leading to an intramolecular cyclization via N-N bond formation.

This one-pot method efficiently synthesizes indazole-3(2H)-ones and 2-aminobenzonitriles using a low-valent titanium reagent and TEA for pH control.

Paper

Efficient and convenient synthesis of indazol-3(2H)-ones and 2-aminobenzonitriles.

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