Paper

Conversion of 1-naphthol to naphthoquinone metabolites by rat liver microsomes: demonstration by high-performance liquid chromatography with reductive electrochemical detection.

Published Dec 1, 1984 · D. Fluck, S. Rappaport, D. Eastmond

Archives of biochemistry and biophysics

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Abstract

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In Vitro Study

Study Snapshot

Rat liver microsomes convert 1-naphthol to cytotoxic naphthoquinone metabolites through iron-dependent lipid peroxidation and superoxide anion generation, potentially explaining its selective toxicity to human colorectal tumor tissue.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Conversion of 1-naphthol to naphthoquinone metabolites by rat liver microsomes: demonstration by high-performance liquid chromatography with reductive electrochemical detection.

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