Conversion of cholic acid to methyl 3α-carbethoxy-12α-acetoxy-6-oxo-5β-chol-7-en-24-oate

doi:10.1016/S0039-128X(02)00182-4

Paper

Conversion of cholic acid to methyl 3α-carbethoxy-12α-acetoxy-6-oxo-5β-chol-7-en-24-oate

Published Mar 1, 2003 · Sean P. Masterson, T. A. Miller, B. Nassim

Steroids

Q2 SJR score

1

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0

Influential Citations

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Abstract

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Study Snapshot

This study presents a new and efficient method for preparing a 7-en-6-one derivative from cholic acid, resulting in methyl 3-carbethoxy-12-acetoxy-6-oxo-5-chol-7-en-24-oate in good yield.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Conversion of cholic acid to methyl 3α-carbethoxy-12α-acetoxy-6-oxo-5β-chol-7-en-24-oate

References

Inhibitors of sterol synthesis. Characterization of side chain oxygenated derivatives formed upon incubation of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one with rat liver mitochondria.

3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one effectively inhibits sterol biosynthesis by forming four major products: (25R)-, (25S)-, and (25S)-3 beta,26-dihydroxy-5 alpha-cholest-8(14)-

Inhibitors of sterol synthesis. Chemical synthesis, structure, and biological activities of (25R)-3 beta,26-dihydroxy-5 alpha-cholest-8(14)-en-15-one, a metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one.

The chemical synthesis of (25R)-3 beta,26-dihydroxy-5 alpha-cholest-8(14)-en-15-one (II) from diosgenin demonstrates its potential as a potent inhibitor of sterol synthesis and its hypocholesterolemic activity.

Synthese d'antibiotiques triterpeniques a partir d'acides biliaires: IV. Etude de l'hydrogenation catalytique du dimethyl-4,4 cholene-5 one-3 oate-24 de methyle

Catalytic hydrogenation of methyl 4,4 dimethyl chol-5 en-3-one-24 oate from lithocholic acid has overcome one of the major difficulties in converting bile acids into tetracyclic triterpene antibiotics.

Citations

Synthesis of the marine furanoditerpene (−)-marginatone

The first formal total synthesis of ()-marginatone 1, a marine labdane furanoditerpene, has been achieved using (+)-coronarin E 5.