Copper-catalyzed one-pot reactions of acetyl chloride, o -halobenzoic acids and Wittig reagents toward 3-methyl isocoumarin synthesis

doi:10.1039/C7RA06707K

Paper

Copper-catalyzed one-pot reactions of acetyl chloride, o -halobenzoic acids and Wittig reagents toward 3-methyl isocoumarin synthesis

Published Jul 28, 2017 · Xuwen Chen, Yunyun Liu

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Abstract

The one-pot reactions of acetyl chloride, o-halobenzoic acids and Wittig reagents providing 3-methyl isocoumarins have been furnished via tandem Wittig reaction, oxa-Michael addition and C–C cross coupling. Three new chemical bonds including one C–O, one CC and one C–C bond are generated via the catalysis of a simple copper salt for the heterocycle construction.

Study Snapshot

Copper-catalyzed one-pot reactions of acetyl chloride, o-halobenzoic acids, and Wittig reagents lead to the synthesis of 3-methyl isocoumarins, providing new chemical bonds for heterocycle construction.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Copper-catalyzed one-pot reactions of acetyl chloride, o -halobenzoic acids and Wittig reagents toward 3-methyl isocoumarin synthesis

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References

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Citations

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