Copper(I) Iodide Catalyzed Cross-Coupling Reaction of Terminal Alkynes with 1-Bromoalkynes: A Simple Synthesis of Unsymmetrical Buta-1,3-diynes

doi:10.1055/S-0030-1259998

Paper

Copper(I) Iodide Catalyzed Cross-Coupling Reaction of Terminal Alkynes with 1-Bromoalkynes: A Simple Synthesis of Unsymmetrical Buta-1,3-diynes

Published May 1, 2011 · Shihua Wang, Lin Yu, Pinhua Li

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Abstract

A simple synthesis of unsymmetrical buta-1,3-diynes by cross-coupling of terminal alkynes with 1-bromoalkynes in the presence of copper(I) iodide and tris(o-tolyl)phosphine was developed that gives good yields under simple and mild reaction conditions. The scope and limitations of the cross-coupling reaction were investigated.

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Copper(I) iodide catalyzed cross-coupling of terminal alkynes with 1-bromoalkynes produces unsymmetrical buta-1,3-diynes with good yields under simple and mild reaction conditions.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Copper(I) Iodide Catalyzed Cross-Coupling Reaction of Terminal Alkynes with 1-Bromoalkynes: A Simple Synthesis of Unsymmetrical Buta-1,3-diynes

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References

Citations

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The iron-based catalytic system effectively generates unsymmetrical 1,3-butadiynes with high selectivity in water under air, enabling the synthesis of 1,3,5-hexatriynes in a one-pot manner.

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This method offers a novel approach to -phenoxyketones, enabling the synthesis of -phenoxy-'-hydroxyketones and,-diphenoxyketones in high yields.

Simple and efficient nickel-catalyzed cross-coupling reaction of alkenylalanes with alkynyl halides for synthesis of conjugated enynes

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Fluorescence self-quenching in 2,5-substituted selenophene derivatives is related to a photoinduced electron-transfer mechanism, with no dependence on solvent polarity on absorption and emission maxima location.