A cost-effective, scalable, high-yielding, and commercially viable synthesis of 4-bromo-1,2-dimethyl-1H-imidazole (1), an important building block to construct various bioactive molecules has been established. The main feature of this method includes the selection of appropriate starting material 1,2-dimethyl-1H-imidazole in which the existing issue of regiomer formation is circumvented and the selective debromination accomplished using isopropyl magnesium chloride.

This study developed a cost-effective, scalable, high-yielding, and commercially viable method for synthesizing 4-bromo-1,2-dimethyl-1H-imidazole, a key building block for bioactive molecules.

Paper

Cost-Effective and Scalable Synthesis of 4-Bromo-1,2-dimethyl-1 H -imidazole: A Key Building Block for Bioactive Molecules

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