The electroreductive intramolecular coupling of phthalimides with aromatic aldehydes in the presence of chlorotrimethylsilane and triethylamine led to five-, six-, and seven-membered cyclized products (58-84%). The electroreductive cyclization was applied to the total synthesis of lennoxamine.

Electroreductive intramolecular coupling of phthalimides with aromatic aldehydes effectively synthesized lennoxamine, a potent anti-inflammatory agent.

Paper

Electroreductive intramolecular coupling of phthalimides with aromatic aldehydes: application to the synthesis of lennoxamine.

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