Covalent binding of a neurotoxic n-hexane metabolite: conversion of primary amines to substituted pyrrole adducts by 2,5-hexanedione.

doi:10.1016/0041-008X(82)90389-1

Paper

Covalent binding of a neurotoxic n-hexane metabolite: conversion of primary amines to substituted pyrrole adducts by 2,5-hexanedione.

Published Sep 30, 1982 · A. DeCaprio, E. Olajos, P. Weber

Toxicology and applied pharmacology

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130

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1

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Abstract

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In Vitro Study

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Study Snapshot

2,5-hexanedione forms substituted pyrrole adducts with primary amines, suggesting pyrrole formation as the probable mode of in vivo tissue binding.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Covalent binding of a neurotoxic n-hexane metabolite: conversion of primary amines to substituted pyrrole adducts by 2,5-hexanedione.

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