Cu2O-catalyzed tandem ring-opening/coupling cyclization process for the synthesis of 2,3-dihydro-1,4-benzodioxins.

doi:10.1021/ol801444p

Paper

Cu2O-catalyzed tandem ring-opening/coupling cyclization process for the synthesis of 2,3-dihydro-1,4-benzodioxins.

Published Jul 30, 2008 · W. Bao, Yunyun Liu, Xin Lv

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53

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Abstract

2,3-Dihydro-1,4-benzodioxins can be prepared in a tandem one-pot procedure by reaction of o-iodophenols with epoxides catalyzed by Cu2O/1,10-phenanthroline/Cs2CO3 system. The reaction is suggested to occur via a novel ring-opening/coupling mechanism, giving moderate to good yields. Moreover, both aryl and aliphatic epoxides are tolerated under these conditions.

Study Snapshot

This Cu2O-catalyzed tandem ring-opening/coupling cyclization process allows for the synthesis of 2,3-dihydro-1,4-benzodioxins in a one-pot procedure, with moderate to good yields and tolerance for both aryl and

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Cu2O-catalyzed tandem ring-opening/coupling cyclization process for the synthesis of 2,3-dihydro-1,4-benzodioxins.

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References

Citations

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