An efficient Cu-catalyzed direct sulfonylation of indolines with easily accessible sulfonyl chlorides has been realized under air atmosphere via chelation-assisted strategy. This protocol exhibits several unique characteristics, including broad substrate scope, good functional group tolerance, and operational convenience, which enables a regioselective access to a variety of C-7 functionalized indoline scaffolds in moderate to good yields. The mechanistic study reveals that sulfonyl radical might be involved in this transformation.

This Cu-catalyzed direct sulfonylation of indolines with sulfonyl chlorides enables regioselective access to various C-7 functionalized indoline scaffolds in moderate to good yields, with sulfonyl radical possibly

Paper

Cu-Catalyzed Direct C7-Sulfonylation of Indolines with Arylsulfonyl Chlorides.

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