Cu-Catalyzed Direct C7-Sulfonylation of Indolines with Arylsulfonyl Chlorides.

doi:10.1021/acs.joc.9b02954

Paper

Cu-Catalyzed Direct C7-Sulfonylation of Indolines with Arylsulfonyl Chlorides.

Published Dec 13, 2019 · Changlei Zhi, Qiuling Wang, Shuang‐Liang Liu

The Journal of organic chemistry

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25

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Abstract

An efficient Cu-catalyzed direct sulfonylation of indolines with easily accessible sulfonyl chlorides has been realized under air atmosphere via chelation-assisted strategy. This protocol exhibits several unique characteristics, including broad substrate scope, good functional group tolerance, and operational convenience, which enables a regioselective access to a variety of C-7 functionalized indoline scaffolds in moderate to good yields. The mechanistic study reveals that sulfonyl radical might be involved in this transformation.

Study Snapshot

This Cu-catalyzed direct sulfonylation of indolines with sulfonyl chlorides enables regioselective access to various C-7 functionalized indoline scaffolds in moderate to good yields, with sulfonyl radical possibly

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Cu-Catalyzed Direct C7-Sulfonylation of Indolines with Arylsulfonyl Chlorides.

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References

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Citations

Ru(II)-Catalyzed C7 Trifluoromethylthiolation and Thioarylation of Indolines Using Bench-Stable Reagents.

Ru(II)-catalyzed C7 trifluoromethylthiolation and thioarylation of indolines using bench-stable reagents provides good to excellent yields for functionalizing diversely substituted indolines at C7 position.

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