Cyclized substituted thioureas. I. Preparation of some 3-substituted 1,2,3,4-tetrahydroquinazoline-2-thiones and their intermediates.

doi:10.1002/JPS.2600501016

Paper

Cyclized substituted thioureas. I. Preparation of some 3-substituted 1,2,3,4-tetrahydroquinazoline-2-thiones and their intermediates.

Published Oct 1, 1961 · R. Orth, J. Jones

Journal of pharmaceutical sciences

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9

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0

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Abstract

Abstract Some 3-substituted 1,2,3,4-tetrahydroquinazoline-2-thiones were prepared by first synthesizing the N-substituted- o -nitrobenzylamines, then the corresponding N-substituted- o -aminobenzylamines. The tetrahydroquinazoline-2-thiones were then obtained by refluxing the diamine with carbon disulfide. It is suggested that antithyroidal, antitubercular, and/or antifungal properties might be present in these condensed ring thiones.

Study Snapshot

3-substituted 1,2,3,4-tetrahydroquinazoline-2-thiones show potential antithyroidal, antitubercular, and/or antifungal properties, potentially due to their condensed ring thiones.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Cyclized substituted thioureas. I. Preparation of some 3-substituted 1,2,3,4-tetrahydroquinazoline-2-thiones and their intermediates.

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