Paper
Cyclocondensation of 2-Fluoro-5-nitrobenzaldehyde with Amidines. New Synthesis of Isoquinolines
Published Jul 1, 2004 · D. Dar'in, S. Selivanov, P. Lobanov
Chemistry of Heterocyclic Compounds
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Abstract
The direction of the cyclocondensation of 2-fluoro-5-nitrobenzaldehyde with five amidines having α-hydrogen atoms has been studied. It was established that depending on the structure of the amidine the main products of the reaction may be not only quinazolines but also 3-aminoisoquinolines. A new convenient route has been found for the synthesis of 3-aminoisoquinolines consisting of the cyclocondensation of α-acylacetamidines with 2-fluoro-5-nitrobenzaldehyde.
Cyclocondensation of 2-fluoro-5-nitrobenzaldehyde with -hydrogen atoms in amidines can produce 3-aminoisoquinolines, offering a new convenient route for their synthesis.
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