Selective cytotoxicity of marine-derived fungal metabolite (3S,6S)-3,6-dibenzylpiperazine-2,5-dione against cancer cells adapted to nutrient starvation

doi:10.1038/s41429-020-0340-3

Paper

Selective cytotoxicity of marine-derived fungal metabolite (3S,6S)-3,6-dibenzylpiperazine-2,5-dione against cancer cells adapted to nutrient starvation

Published Jun 25, 2020 · Rui Tang, Dongyi Zhou, Atsushi Kimishima

The Journal of Antibiotics

Q3 SJR score

7

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Abstract

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In Vitro Study

Study Snapshot

The marine-derived fungal metabolite (3S,6S)-3,6-dibenzylpiperazine-2,5-dione selectively kills cancer cells adapted to nutrient starvation, potentially through uncoupling of mitochondrial oxidative phosphorylation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Selective cytotoxicity of marine-derived fungal metabolite (3S,6S)-3,6-dibenzylpiperazine-2,5-dione against cancer cells adapted to nutrient starvation

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