A number of deaza analogues of adenosine were prepared and tested as inhibitors of platelet aggregation induced by ADP and collagen to investigate the structure-activity relationships in this class of nucleoside analogues. The results showed that the presence of a 6-amino group and nitrogen atoms at positions 3 and 7 of the purine moiety are required for inhibitory activity.

Deaza analogues of adenosine with 6-amino group and nitrogen atoms at positions 3 and 7 effectively inhibit platelet aggregation induced by ADP and collagen.

Paper

Deaza analogues of adenosine as inhibitors of blood platelet aggregation.

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