Paper

Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents.

Published Jan 7, 2015 · DOI · Maria Laura Pati, C. Abate, M. Contino

European journal of medicinal chemistry

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Abstract

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Study Snapshot

Deconstructing 6,7-dimethoxytetrahydroisoquinoline moiety in mixed P-gp/2 receptor agents can lead to the separation of 2 receptor affinity from P-gp activity, resulting in P-gp selective agents without 2 receptor affinity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents.

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