Delayed hypersensitivity reaction to hyaluronic acid dermal filler following influenza-like illness

doi:10.2147/CCID.S198081

Paper

Delayed hypersensitivity reaction to hyaluronic acid dermal filler following influenza-like illness

Published Apr 1, 2019 · M. Turkmani, K. De Boulle, W. Philipp-Dormston

Clinical, Cosmetic and Investigational Dermatology

Q2 SJR score

66

Citations

8

Influential Citations

Full textSemantic Scholar

Abstract

Background: Delayed reactions after facial hyaluronic acid injection are relatively rare complications. Their cause may be infectious or immune-mediated in origin, and their outbreak can be triggered, for example, by an influenza-like illness. Objective: To describe potential adverse event of influenza like illness following dermal filler injection. Methods: We report fourteen unusual cases of delayed hypersensitivity reaction to several brands of hyaluronic acid dermal filler following influenza like illness. Results: Increasing evidence implicates influenza infection in the pathogenesis of late onset filler reaction. Conclusion: Although there is a low risk of late onset adverse reaction with hyaluronic acid fillers, injecting physicians must be aware of the possible filler reaction following the influenza infection.

Case Report

Rigorous Journal

Study Snapshot

Delay in hyaluronic acid dermal filler reaction following influenza-like illness is a rare but potential side effect, requiring physicians to be aware of this potential risk.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Delayed hypersensitivity reaction to hyaluronic acid dermal filler following influenza-like illness

References

Late-Onset Inflammatory Response to Hyaluronic Acid Dermal Fillers

Late-onset inflammatory reactions to hyaluronic acid fillers are self-limiting and easily treatable with oral steroids and hyaluronidase, likely due to Type IV delayed hypersensitivity response.

Immunological reaction after facial hyaluronic acid injection

Hyaluronic acid injections can cause rare inflammatory reactions in the face, with immune-mediated delayed hypersensitivity reactions being the most likely cause.

Global Aesthetics Consensus: Avoidance and Management of Complications from Hyaluronic Acid Fillers—Evidence- and Opinion-Based Review and Consensus Recommendations

Adverse reactions to hyaluronic acid fillers are uncommon, but proper planning, technique, and understanding of facial anatomy can help reduce the risk and be prepared for any complications that arise.

Etiology, Prevention, and Management of Infectious Complications of Dermal Fillers

Early, late, and delayed infectious complications of dermal fillers can be prevented through thorough patient history, sterile technique, and minimizing tissue trauma.

Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology

Hyaluronan signaling properties are influenced by fragment size, not post-synthesis molecular modification, and this affects their downstream biological effects.

Citations