Quaternary Derivatives of Benzoyltropine and Benzoyl-ψ-tropine with Anticholinergic and Local Anæsthetic Properties

doi:10.1038/171788A0

Paper

Quaternary Derivatives of Benzoyltropine and Benzoyl-ψ-tropine with Anticholinergic and Local Anæsthetic Properties

Published May 2, 1953 · L. Gyermek

Nature

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Abstract

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Study Snapshot

Quaternary derivatives of benzoyltropine and benzoyl--tropine show varying effects on cholinergic-blocking actions and local anesthetic properties, with stereo-structure playing a significant role in their pharmacological effects.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Quaternary Derivatives of Benzoyltropine and Benzoyl-ψ-tropine with Anticholinergic and Local Anæsthetic Properties

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References

Stereochemistry of the Tropane Alkaloids

Atropine, hyoscyamine, and convolamine are anti-3-tropanol structures, while tropine and nortropine are hydroxyl-containing psi-tropine derivatives.

Citations

The ability of Ibutropin to blunt fentanyl-induced respiratory depression is independent of its activation of carotid body chemoafferents

Ibutropin's ability to blunt fentanyl-induced respiratory depression may involve mechanisms in central respiratory control centers and peripheral structures other than carotid bodies.

Tropine exacerbates the ventilatory depressant actions of fentanyl in freely-moving rats

Tropine worsens the ventilatory depressant effects of fentanyl in freely-moving rats, potentially due to its ability to readily enter peripheral and central cells.

The Quaternary Lidocaine Derivative, QX-314, Produces Long-lasting Local Anesthesia in Animal Models In Vivo

QX-314 produces long-lasting local anesthesia with a slow onset in animal models, challenging the conventional notion that these agents are ineffective when applied extracellularly.

Chemical nature and pharmacological actions of quaternary ammonium salts.

Quaternary ammonium salts induce diverse pharmacological responses by altering acetylcholine-like actions in various organs and tissues, with variations in test dosage, time, and test species.